您所在的位置: 首页 >> 期刊 >> 生物工程前沿

生物工程前沿

《生物工程前沿》是IVY出版社旗下的一本关注生物工程技术发展的综合性国际期刊,主要刊登生物技术工程、微生物、医药、农林、食用菌、轻工食品、环保、食用菌及相关生物学领域内最新研究进展的学术性论文、评论性文章和研究综述性文章,旨在为该领域内的专家、学者、科研人员、管理人员提供一个良好的传播、分享和探讨学科研究进展的交流平台,反映学术前沿水平,促进学术交流,促进生物技术的发展。本刊可接收中、英文稿件。其中,中文稿件要有详细的英文标题、作者、单位…… 【更多】 《生物工程前沿》是IVY出版社旗下的一本关注生物工程技术发展的综合性国际期刊,主要刊登生物技术工程、微生物、医药、农林、食用菌、轻工食品、环保、食用菌及相关生物学领域内最新研究进展的学术性论文、评论性文章和研究综述性文章,旨在为该领域内的专家、学者、科研人员、管理人员提供一个良好的传播、分享和探讨学科研究进展的交流平台,反映学术前沿水平,促进学术交流,促进生物技术的发展。

本刊可接收中、英文稿件。其中,中文稿件要有详细的英文标题、作者、单位、摘要和关键词。初次投稿请作者按照稿件模板排版后在线投稿。稿件会经过严格、公正的同行评审步骤,录用的稿件首先发表在本刊的电子刊物上,然后高质量印刷发行。期刊面向全球公开征稿、发行,要求来稿均不涉密,文责自负。

ISSN Print:2327-0837

ISSN Online:2327-0888

Email:bf@ivypub.org

Website: http://www.ivypub.org/bf/

  0
  0

Paper Infomation

Novel Coronavirus Disease 2019 (COVID-19) Pandemic: Research Progress of Current Medical Therapy

Full Text(PDF, 35KB)

Author: Hongji Li

Abstract: The novel coronavirus outbreak in Wuhan, Hubei Province, China in late December 2019 which poses a serious threat to the whole world. At present, the number of cases of infection is still rising. Most patients have symptoms of fever, cough and diarrhea in the early stage of the disease, and they are mainly diagnosed with pneumonia in the later stage. This disease develops rapidly, so it is very important to use drugs reasonably and treat it in the early stage. Preliminary reports indicate that certain drugs, such as chloroquine and antiviral nucleotide analogues, such as remdesivir and lopinavir/ritonavir, which inhibits viral replication, can target new coronavirus and many also used traditional Chinese medicine and other secondary therapy, although their clinical use is still under debate. Besides, scientists all over the world are racing to produce an effective vaccine for the coronavirus. This paper reviews current medical treatment strategies, and aims to provide references for new drug development and clinical workers.

Keywords: Novel Coronavirus, Clinical Trial, Drug Therapy, Potential Drug Development

References:

[1] ZHU N, ZHANG D, WANG W, et al. A novel coronavirus from patients with pneumonia in China, 2019[J]. N Engl J Med, 2020, 382(8):727- 33.

[2] World Health Organization. Coronavirus disease 2019 (COVID-19) situation report-104. https://www.who.int/docs/default-source/coronaviruse/situation-reports/ 20200503-covid-19-sitrep-104.pdf?sfvrsn=53328f46_2, Accessed date: 3 May 2020.

[3] World Health Organization(WHO). Coronavirus disease (COVID-19) outbreak[EB/OL]. (2020-02-17)/(2020-07-03).https://www.who.int/

[4] CORONAVIRIDAE STUDY GROUP OF THE INTERNATIONAL COMMITTEE ON TAXONOMY OF VIRUSES (ICTV). Naming the 2019 Coronavirus[EB/OL].(2020-02-05). https://talk.ictvonline.org/information/w/news/1300/page

[5] Real-time Data Report on the Novel Coronavirus Pneumonia Epidemic[EB/OL].(2020-08-14). https://voice.baidu.com/act/newpneumonia/newpneumonia/?from=osari_aladin_banner

[6] Siyi Xin,Xueqi Cheng,Bo Zhu,Xiaolong Liao,Feng Yang,Lina Song,Yan Shi, et al. Clinical retrospective study on the efficacy of Qingfei Paidu decoction combined with Western medicine for COVID-19 treatment[J]. Biomedicine & Pharmacotherapy, 2020, 129.

[7] Cho A, Saunders OL, Butler T, et al. Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7, 9-dideazaadenosine C-nucleosides[J]. Bioorg Med Chem Lett, 2012, 22(8): 2705-2707. DOI: 10.1016/j.bmcl.2012.02.105.

[8] Sheahan TP, Sims AC, Graham RL, et al. Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotie coronaviruses[J]. Sci Transl Med, 2017, 9(396):36-53

[9] Warren TK, Jordan R, Lo MK, et al. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys[J]. Nature, 2016, 531(7594): 381-385. DOI: 10.1038/nature17180.

[10] Runfeng L, Nanshan Z, Zifeng Y et al. Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2), Pharmacological Research (2020), doi: https://doi.org/10.1016/j.phrs.2020.10476

[11] Wang M, Cao R, Zhang L, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019- nCoV) in vitro[J]. Cell Res, 2020, 30(3): 269-271. DOI: 10.1038/ s41422-020-0282-0

[12] Holshue ML, DeBolt C, Lindquist S, et al. First case of 2019 novel coronavirus in the United States[J]. N Engl J Med, 2020, 382(10): 929-936. DOI: 10.1056/NEJMoa2001191.

[13] Yeming Wang, Dingyu Zhang, Bin Cao, Chen Wang, et al. Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial[J]. TheLancet, https://doi.org/10.1016/S0140-6736(20)31022-9

[14] J.H. Beigel, K.M. Tomashek, L.E. Dodd, A.K. Mehta, et al. Remdesivir for the Treatment of Covid-19—PreliminaryReport[J].The New England journal of medicine DOI : 10. 1056/ NEJ Moa2007764

[15] Gilead Announces Results From Phase 3 Trial of Investigation Antiviral Remdesivir in Patients With Severe COVID-19[EB/OL]. https://www.gilead.com/news-and-press/press-room/press-releases/2020/4/

[16] Van Vugt M, White NJ. The treatment of chloroquine-resistant malaria [J]. Trop Doct, 1999, 29: 176-179.

[17] Plantone D, Koudriavtseva T. Current and future use of chloro‐ quine and hydroxychloroquine in infectious, immune, neoplastic, and neurological diseases: a mini-review [J]. Clin Drug Invest, 2018, 38: 653-671.

[18] Adrea Savarino, John R Boelaert, Antonio Cassone, Giancario Majori, Roberto Cauda. Effects of chloroquine on viral infections: an old drug against today’s diseases[J] . The Lancet Infectious Diseases. 2003 (11)

[19] MohsinKhan, S.R. Santhosh, Mugdha Tiwari, P.V. LakshmanaRao, ManmohanParida. Assessment of in vitro prophylactic and therapeutic efficacy of chloroquine against chikungunya virus in vero cells[J] . Med. Virol. 2010 (5)

[20] National Health Commission of the People's Republic of China: Notice on printing and distributing the diagnosis and treatment plan of pneumonia with new coronavirus infection (trial version 7) [EB/OL]. Medical administration and hospital authority, 2020 [2020-03-04]. http://www.nhc.gov.cn/yzygj/s7653p/202003/ 46c9294a7dfe4cef80dc7f5912eb1989.shtml

[21] Joshua Geleris, M.D., Yifei Sun, Ph.D., Jonathan Platt, et al. Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19[J]. The New England journal of medicine, DOI: 10.1056/NEJMoa2012410

[22] Tang W, Cao Z , Han M , et al. Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial[J]. BMJ (online), 2020, 369:m1849.

[23] Hoffmann, M., Mösbauer, K., Hofmann-Winkler, H. et al. Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2. Nature (2020). https://doi.org/10.1038/s41586-020-2575-3

[24] National Health Commission, Office of the State Administration of Traditional Chinese Medicine. New Coronavirus Pneumonia Diagnosis and Treatment Plan (Trial Version 7) [EB/OL].(2020-03-04)/(2020-07-16).http://www.nhc.gov.cn/yzygjhttp://www.nhc.gov.cn/yzygj/s7653p/202003/46c9294a7dfe4cef80dc7f5912eb1989.shtml.

[25] Zhu Shunya, Li Xiaoyu, Wei Yunling, et al. Preliminary study on the in vitro inhibitory effects of three traditional Chinese medicine prescriptions on SARS-related coronavirus[J].Biotechnology Communications,2003(5):390-392.

[26] Ding Xinkan. Pharmacological analysis of Lianhua Qingwen drug against influenza virus[J].Journal of Clinical Rational Use of Medicines,2012,5(28):32

[27] Niu Ming, Wang Ruilin, Wang Zhongxia, et al. The rapid selection mode and application of anti-new coronavirus TCM prescriptions based on clinical experience and molecular docking technology [J/OL]. Chinese Journal of Chinese Materia Medica: 1-8

[28] Runfeng L, Nanshan Z, Zifeng Y et al. Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2), Pharmacological Research (2020), doi: https://doi.org/10.1016/j.phrs.2020.10476

[29] Ke Hu, Wei-jie Guan, Ying Bi, Zhen-hua Jia, Nan-shan Zhong, et al. Efficacy and safety of Lianhuaqingwen capsules, a repurposed Chinese herb, in patients with coronavirus disease 2019: A multicenter, prospective, randomized controlled trial[J]. Phytomedicine, 2020.

[30] Croxtall JD, Perry CM. Lopinavir/ritonavir [J]. Drugs, 2010, 70: 1885-1915

[31] Chu MC. Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings [J]. Thorax, 2004, 59: 252-256

[32] Nukoolkarn V, Lee VS, Malaisree M, et al. Molecular dynamic simulations analysis of ritronavir and lopinavir as SARS-CoV 3CLpro inhibitors [J]. J Theor Biol, 2008, 254: 861-867.

[33] Stockman LJ, Bellamy R, Garner P. SARS: systematic review of treatment effects [J]. PLoS Med, 2006, 3: e343

[34] Chen J, Ling Y, Xi XH, et al. Efficacies of lopinavir/ritonavir and abidol in the treatment of novel coronavirus pneumonia [J]. Infect Disease of China, 2020, 38: 86-89.

[35] B. Cao, Y. Wang, D. Wen, W. Liu, Jingli Wang, et al. A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19[J]. The New England journal of medicine, DOI :10.1056 / NEJMoa2001282

[36] WANG K, CHEN W, ZHOU Y, et al. SARS-CoV-2 invades host cells via a novel route: CD147-spikeprotein[EB/OL].(2020-03-10)/(2020-07-22).https://www.biorxiv.org/content/10.1101/2020.03.14.988345v1.full.pdf.

[37] Shiva Shaghaghi,Mahyar Daskareh,Mona Irannejad,Mohammadreza Shaghaghi,Ihab R. Kamel. Target-shaped combined halo and reversed-halo sign, an atypical chest CT finding in COVID-19[J]. Clinical Imaging, 2021, 69.

[38] TIAN Xiaolong, LI Cheng, HUANG Ailing, et al. Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody[J]. Emerg Microbes Infect, 9 (1): 382-385.

[39] CHEN J, ZHU H, HORBY P W, et al. Specificity, kinetics and longevity of antibody responses to avian influenza A(H7N9) virus infection in humans[J]. J Infect, 2020, 80(3):310-319.

[40] ARABI Y M, HAJEER A H, LUKE T, et al. Feasibility of using convalescent plasma immunotherapy for MERS-CoV infection, Saudi Arabia[J]. Emerg Infect Dis, 2016, 22(9):1554-61.

[41] K. Duan, B. Liu, C. Li, et al. Effectiveness of convalescent plasma therapy in severe COVID-19 patients, Proc. Natl. Acad. Sci. U.S.A. 117 (2020) 9490–9496

[42] M. Ye, D. Fu, Y. Ren, et al. Treatment with convalescent plasma for COVID-19 patients in Wuhan, China, J. Med. Virol. (2020)

[43] Hassan Abolghasemia, Peyman Eshghib, Abdol Majid Cheraghali, et al. Clinical efficacy of convalescent plasma for treatment of COVID-19 infections: Results of a multicenter clinical study[J]. Transfusion and Apheresis Science (in press)

Privacy Policy | Copyright © 2011-2024 Ivy Publisher. All Rights Reserved.

Contact: customer@ivypub.org