Doxycycline's Effects on Symptoms and Inflammatory Response in Children with Mycoplasma Pneumoniae Pneumonia: A Safety Analysis

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Biotechnology Frontier

Biotechnology Frontier (Yearly) is an international comprehensive professional academic journal of Ivy Publisher, concerning the development of biotechnology technology. The main focus of the journal is the academic papers, comments and research review of latest improvement in the fields of Biotechnology technology, microorganism, medicine, agriculture & forestry, edible fungus, light food, environmental protection and related, aiming at... [More] Biotechnology Frontier (Yearly) is an international comprehensive professional academic journal of Ivy Publisher, concerning the development of biotechnology technology. The main focus of the journal is the academic papers, comments and research review of latest improvement in the fields of Biotechnology technology, microorganism, medicine, agriculture & forestry, edible fungus, light food, environmental protection and related, aiming at providing a good communication platform to transfer, share and discuss the theoretical and technical development of electrical theory development for professionals, scholars, researchers and administrative staffs in this field, reflecting the academic front level, promote academic change and foster the development of biotechnology technology.

The journal receives manuscripts written in Chinese or English. As for Chinese papers, the following items in English are indispensible parts of the paper: paper title, author(s), author(s)'affiliation(s), abstract and keywords. If this is the first time you contribute an article to the journal, please format your manuscript as per the sample paper and then submit it into the online submission system. Accepted papers will immediately appear online followed by printed hard copies by Ivy Publisher globally. Therefore, the contributions should not be related to secret. The author takes sole responsibility for his views.

ISSN Print:2327-0837

ISSN Online:2327-0888

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This journal is full-text indexed by Centre Agriculture Bioscience International (CABI), which is one of the world's three major agriculture literature database.

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Paper Infomation

Doxycycline's Effects on Symptoms and Inflammatory Response in Children with Mycoplasma Pneumoniae Pneumonia: A Safety Analysis

Full Text(PDF, 36KB)

Author: Fuqiang Zhang

Abstract: Objective: To evaluate the clinical efficacy of doxycycline in treating Mycoplasma pneumoniae pneumonia (MPP) in children. Methods: A total of 78 MPP patients treated in our hospital from September 2024 to October 2025 were randomly divided into groups. The reference group (39 cases) received azithromycin sequential therapy, while the study group (39 cases) was treated with doxycycline. The therapeutic outcomes of both groups were observed. Results: After treatment, the study group exhibited shorter durations for the disappearance of main symptoms and signs compared to the reference group (P < 0.05). Post-treatment, the study group showed lower levels of CRP, TNF-α, and IL-8, along with a higher overall clinical efficacy rate compared to the reference group (P < 0.05). No statistically significant difference was observed in the incidence of adverse drug reactions between the two groups (P > 0.05). Conclusion: In the clinical treatment of MPP in children, doxycycline demonstrates superior efficacy in alleviating core symptoms (fever, cough) and mitigating systemic inflammatory responses, with a higher overall clinical efficacy rate and favorable safety profile.

Keywords: Mycoplasma Pneumoniae Pneumonia; Doxycycline; Symptoms; Inflammatory Response

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