Paper Infomation
Doxycycline's Effects on Symptoms and Inflammatory Response in Children with Mycoplasma Pneumoniae Pneumonia: A Safety Analysis
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Author: Fuqiang Zhang
Abstract: Objective: To evaluate the clinical efficacy of doxycycline in treating Mycoplasma pneumoniae pneumonia (MPP) in children. Methods: A total of 78 MPP patients treated in our hospital from September 2024 to October 2025 were randomly divided into groups. The reference group (39 cases) received azithromycin sequential therapy, while the study group (39 cases) was treated with doxycycline. The therapeutic outcomes of both groups were observed. Results: After treatment, the study group exhibited shorter durations for the disappearance of main symptoms and signs compared to the reference group (P < 0.05). Post-treatment, the study group showed lower levels of CRP, TNF-α, and IL-8, along with a higher overall clinical efficacy rate compared to the reference group (P < 0.05). No statistically significant difference was observed in the incidence of adverse drug reactions between the two groups (P > 0.05). Conclusion: In the clinical treatment of MPP in children, doxycycline demonstrates superior efficacy in alleviating core symptoms (fever, cough) and mitigating systemic inflammatory responses, with a higher overall clinical efficacy rate and favorable safety profile.
Keywords: Mycoplasma Pneumoniae Pneumonia; Doxycycline; Symptoms; Inflammatory Response
References:
[1] 姬涛,韩国敬,宋玉祥,等.161例肺炎支原体肺炎临床特征[J].中华医院感染学杂志,2025,35(10):1478-1482.
[2] 林秋玉,海元平,李永秀,等.左氧氟沙星及多西环素治疗大环内酯类无反应性肺炎支原体肺炎临床分析[J].海南医科大学学报,2025,31(16):1263-1270.
[3] 王琳,邢玉凤,王一川,等.岩盐气溶胶疗法联合阿奇霉素序贯治疗儿童肺炎支原体肺炎的疗效[J].西北药学杂志,2025,40(6):7-13.
[4] 宋卫娜,王淑华,于淑静.穴位贴敷联合多西环素对痰热闭肺证儿童肺炎支原体肺炎合并肺实变的临床研究[J].中医药学报,2026,54(1):86-90.
[5] 李珊珊,郑吉善,陈燕燕,等.多西环素治疗8岁以下儿童大环内酯类药物无反应性肺炎支原体肺炎的临床观察[J].中国药房,2025,36(4):464-468.
[6] 车家慧,孙舒,姜鑫鑫,等.金振口服液联合多西环素治疗儿童难治性支原体肺炎的疗效和安全性研究[J].中国医院用药评价与分析,2025,25(9):1094-1096,1101.
[7] 朱德胜,贺杰,肖政辉,等.多西环素在儿童重症耐大环内酯类肺炎支原体肺炎应用分析[J].中国小儿急救医学,2025,32(2):122-127.
[8] 崔雪琴,韩国宏,任启波.多西环素治疗阿奇霉素耐药儿童肺炎支原体肺炎的效果[J].中华医院感染学杂志,2024,34(20):3108-3112.