Analysis of the Efficacy of Tiotropium Bromide in the Treatment of Chronic Obstructive Pulmonary Disease

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Biotechnology Frontier

Biotechnology Frontier (Yearly) is an international comprehensive professional academic journal of Ivy Publisher, concerning the development of biotechnology technology. The main focus of the journal is the academic papers, comments and research review of latest improvement in the fields of Biotechnology technology, microorganism, medicine, agriculture & forestry, edible fungus, light food, environmental protection and related, aiming at... [More] Biotechnology Frontier (Yearly) is an international comprehensive professional academic journal of Ivy Publisher, concerning the development of biotechnology technology. The main focus of the journal is the academic papers, comments and research review of latest improvement in the fields of Biotechnology technology, microorganism, medicine, agriculture & forestry, edible fungus, light food, environmental protection and related, aiming at providing a good communication platform to transfer, share and discuss the theoretical and technical development of electrical theory development for professionals, scholars, researchers and administrative staffs in this field, reflecting the academic front level, promote academic change and foster the development of biotechnology technology.

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Paper Infomation

Analysis of the Efficacy of Tiotropium Bromide in the Treatment of Chronic Obstructive Pulmonary Disease

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Author: Guofang Xie

Abstract: Objective: To investigate the clinical efficacy and safety of the long-acting anticholinergic drug tiotropium bromide in the treatment of chronic obstructive pulmonary disease (COPD). Methods: A total of 158 COPD patients admitted from November 2023 to September 2025 were selected as the study subjects. A randomized controlled trial design was adopted, dividing the patients into a tiotropium bromide intervention group (n=79) and a conventional treatment control group (n=79). The intervention group inhaled 18 μg of tiotropium bromide daily, while the control group received short-acting ipratropium bromide and bronchodilators. The main outcome measures included forced expiratory volume in one second (FEV1), FEV1 as a percentage of predicted value (FEV1%pred), COPD Assessment Test (CAT) score, modified British Medical Research Council (mMRC) dyspnea scale score, and the frequency of acute exacerbations. The treatment course was 24 weeks. Results: After 24 weeks of treatment, the tiotropium bromide group showed an increase in FEV1 from baseline by (0.31 ± 0.08) L and an improvement in FEV1%pred by (10.2 ± 2.5)%, which were significantly higher than those in the control group [(0.12 ± 0.05) L and (4.1 ± 1.8)%, respectively (P < 0.01)]. The tiotropium bromide group also demonstrated greater reductions in CAT score [(-7.6 ± 1.2) points] and mMRC score [(-1.8 ± 0.3) points] compared to the control group [(-3.1 ± 0.9) points and (-0.7 ± 0.2) points, respectively (P < 0.01)]. The incidence of acute exacerbations in the intervention group was reduced to 12.7% (10/79), while it was 31.6% (25/79) in the control group (RR = 0.40, 95% CI: 0.21–0.76). There was no statistically significant difference in the incidence of severe adverse events between the two groups (6.3% vs. 5.1%, P > 0.05). Conclusion: Long-term treatment with tiotropium bromide can significantly improve lung function and clinical symptoms in COPD patients, reduce the risk of acute exacerbations, and has a controllable safety profile.

Keywords: Chronic Obstructive Pulmonary Disease; Tiotropium Bromide; Lung Function; Dyspnea; Acute Exacerbation

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