Paper Infomation
Preparation and Characterization of Norfloxacin Chitosan Microspheres
Full Text(PDF, 1915KB)
Author: Rong Pan, Ziru Lian, Jiangtao Wang
Abstract: Norfloxacin (NFX)/ Chitosan (CS) microspheres were prepared by using inverse emulsion polymerization and cross-linking method. Glutaraldehyde was used as cross linker. Orthogonal design based on 4 factors: core-shell ratio, chitosan concentration, dosage of cross linker, agitation speed. Based on the entrapment efficiency and drug loading content of microspheres by orthogonal array analysis, the optimum condition for microspheres preparation was: core-shell ratio = 1:10, chitosan concentration (w/ v) = 4%, dosage of cross linker (v/ v) = 1%, agitation speed = 800 rpm. The microspheres were characterised by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). Cumulative release profile of NFX from the microspheres in seawater was measured in 48 h. The drug released slower as chitosan increases.
Keywords: Norfloxacin; Chitosan; Microspheres; Seawater; Controlled Release
References:
[1] Wang A Q,Chitin Chemistry[M]. Science Press, 2008
[2] Yang T, Hou W L, Yang Y D.The Preparation of Chitosan Microspheres and Application in Biology and Medicine[J]. Polymer Bulletin 2011 (5): 51-56
[3] Hua S, Yang H, Wang W, et al. Controlled release of ofloxacin from chitosan–montmorillonite hydrogel[J]. Applied Clay Science, 2010, 50(1): 112-117
[4] Hui P C L, Wang W Y, Kan C W, et al. Preparation and characterisation of chitosan microcapsules loaded with Cortex Moutan[J]. International journal of biological macromolecules, 2013, 55: 32-38
[5] Huang L, Sui W, Wang Y, et al. Preparation of chitosan/chondroitin sulfate complex microcapsules and application in controlled release of 5-fluorouracil[J]. Carbohydrate Polymers, 2010, 80(1): 168-173
[6] Guo H Y, Ma Y G, Zhu L,et al. The Pharmacokinetics and Residual Regulation of Quinolones in Aquatic Animals[J].Journal of Hydroecology, 2008, 1(1): 34-41
[7] Zhang Z F, Zhou J P, Huo M R.Chitosan Microspheres Drug Delivery Systems[J]. Progress in Pharmaceutical Sciences, 2006, 30(6): 261-266
[8] Wang S, Ye G H, Zheng M Y,et al.The Application of Chitosan Microsphere[J]. Chemical Intermediates, 2008 (1): 30-34
[9] Shi H T, Wei M Y. Methods of prevention of Penaeus vannamei Vibrio[J].Shandong Fisheries, 2005, 22(3): 36-36