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Scientific Journal of Frontier Chemical Development

ISSN Print:2167-163X

ISSN Online:2167-1648

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Preparation and Characterization of Norfloxacin Chitosan Microspheres

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Author: Rong Pan, Ziru Lian, Jiangtao Wang

Abstract: Norfloxacin (NFX)/ Chitosan (CS) microspheres were prepared by using inverse emulsion polymerization and cross-linking method. Glutaraldehyde was used as cross linker. Orthogonal design based on 4 factors: core-shell ratio, chitosan concentration, dosage of cross linker, agitation speed. Based on the entrapment efficiency and drug loading content of microspheres by orthogonal array analysis, the optimum condition for microspheres preparation was: core-shell ratio = 1:10, chitosan concentration (w/ v) = 4%, dosage of cross linker (v/ v) = 1%, agitation speed = 800 rpm. The microspheres were characterised by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). Cumulative release profile of NFX from the microspheres in seawater was measured in 48 h. The drug released slower as chitosan increases.

Keywords: Norfloxacin; Chitosan; Microspheres; Seawater; Controlled Release

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